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What is Goodpasture syndrome?
Goodpasture syndrome is a group of acute illnesses that affects the lungs and kidneys. It involves an autoimmune disorder. Normally, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to an inflammation of the kidneys (glomerulonephritis) and kidney failure. It can be fatal if not quickly diagnosed and treated.
This disease most often occurs in people ages 20 to 30 or those older than age 60. It is more common in men. In some cases, bleeding in the lungs may occur. In most cases, this disease does not cause lasting damage to the lungs. But kidney damage may be long-lasting. If the kidneys fail, kidney transplant or dialysis may be needed.
What causes Goodpasture syndrome?
Medical experts are not certain what causes this disease. It can run in families, so genetics may play a role. Or the disease may occur because of a combination of other factors. These include exposure to certain chemicals, such as dry cleaning chemicals or the weed killer Paraquat. Viral infections, smoking, or medicines may also play a role.
What are the symptoms of Goodpasture syndrome?
These are the most common symptoms of Goodpasture syndrome:
- Lack of energy or tiring easily (fatigue)
- Trouble breathing
- Pale skin
As the condition progresses, other symptoms may occur, including:
- Coughing up blood
- Burning feeling when urinating
Over time, symptoms of kidney involvement may occur, including:
- Small amounts of blood in the urine (hematuria)
- Protein in the urine (proteinuria)
The symptoms of Goodpasture syndrome may look like other conditions or medical problems. Always see your healthcare provider for a diagnosis.
How is Goodpasture syndrome diagnosed?
Your healthcare provider will review your health history and do a physical exam. Other tests include:
- Blood tests. These tests look for high blood levels of waste products that are normally cleared by the kidney into the urine. Circulating antibodies are also found by blood tests.
- Urine tests. Protein may be found in the urine along with red and white blood cells, and groups of cells and cellular material stuck together (granular casts).
- Kidney biopsy. A test in which tissue samples are removed and checked under a microscope.
- Chest X-ray. This looks for changes to the lungs.
What is the treatment for Goodpasture syndrome?
Your healthcare provider will figure out the best treatment for you based on:
- How old you are
- Your overall health and medical history
- How sick you are
- How well you can handle certain medicines, procedures, or therapies
- How long the condition is expected to last
- Your opinion or preference
Treatment may include:
- Immunosuppressive medicines. These medicines keep your immune system from making antibodies. They can also make you at greater risk for infections. So you may also be prescribed antibiotics.
- Corticosteroids. Used to decrease inflammation and tissue damage which helps control bleeding in your lungs.
- Plasmapheresis. This is a process in which blood plasma is removed, cleaned of harmful antibodies, and then returned to your body. It is usually given with steroids.
What are the complications of Goodpasture syndrome?
Even with proper treatment, complications may develop. Your kidney function may decrease to the point of kidney failure. This can require treatment such as dialysis or even a kidney transplant.
When should I call my healthcare provider?If your symptoms get worse or you have new symptoms, let your healthcare provider know.
Key points about Goodpasture syndrome
- Goodpasture syndrome is a rare disorder in which your body mistakenly makes antibodies that attack the lungs and kidneys.
- It most often occurs in people ages 20 to 30 or older than age 60. It is more common in men.
- It can be fatal if not quickly diagnosed and treated.
- If the kidneys fail, dialysis or kidney transplant may be needed.
- Treatment is aimed at reducing the severity of the symptoms and preventing your immune system from destroying kidney and lung tissue.
Tips to help you get the most from a visit to your child’s healthcare provider:
- Know the reason for the visit and what you want to happen.
- Before your visit, write down questions you want answered.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.
- Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.
- Ask if your child’s condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if your child does not take the medicine or have the test or procedure.
- If your child has a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your child’s provider after office hours. This is important if your child becomes ill and you have questions or need advice.
Online Medical Reviewer:
Hanrahan, John, MD
Online Medical Reviewer:
Latif, Walead, DO
Date Last Reviewed:
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