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Clopidogrel Bisulfate Oral tablet

What is this medicine?

CLOPIDOGREL (kloh PID oh grel) helps to prevent blood clots. This medicine is used to prevent heart attack, stroke, or other vascular events in people who are at high risk.

How should I use this medicine?

Take this medicine by mouth with a drink of water. Follow the directions on the prescription label. You may take this medicine with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in vision

  • fever

  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose

  • sudden weakness

  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • headache

  • pain in back or joints

  • stomach upset

What may interact with this medicine?

  • aspirin

  • blood thinners like cilostazol, enoxaparin, ticlopidine, and warfarin

  • certain medicines for depression like citalopram, fluoxetine, and fluvoxamine

  • certain medicines for fungal infections like ketoconazole, fluconazole, and voriconazole

  • certain medicines for HIV infection like delavirdine, efavirenz, and etravirine

  • certain medicines for seizures like felbamate, oxcarbazepine, and phenytoin

  • chloramphenicol

  • fluvastatin

  • isoniazid, INH

  • medicines for inflammation like ibuprofen and naproxen

  • modafinil

  • nicardipine

  • over-the counter supplements like echinacea, feverfew, fish oil, garlic, ginger, ginkgo, green tea, horse chestnut

  • quinine

  • stomach acid blockers like cimetidine, omeprazole, and esomeprazole

  • tamoxifen

  • tolbutamide

  • topiramate

  • torsemide

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature of 59 to 86 degrees F (15 to 30 degrees C). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

  • bleeding disorder

  • bleeding in the brain

  • planned surgery

  • stomach or intestinal ulcers

  • stroke or transient ischemic attack

  • an unusual or allergic reaction to clopidogrel, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Do not stop taking your medicine unless your doctor tells you to.

If you are going to have surgery or dental work, tell your doctor or health care professional that you are taking this medicine.

Certain genetic factors may reduce the effect of this medicine. Your doctor may use genetic tests to determine treatment.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Date Last Reviewed: 4/10/2014
© 2000-2014 The StayWell Company, LLC. 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.