Drug-Drug Severity Levels:

For drug-drug interactions, the severity level is used to classify drug interactions and indicates clinical significance. The drug interactions returned can be filtered to include only interactions of a specified severity level code.

• Severe
  These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.
• Serious
  These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.
• Moderate
  These medicines may cause some risk when taken together. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.
• Unknown
  Alternative Therapy Interaction. Warning: These medications may cause some risk when taken together. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.

Drug-Food Significance Levels:

Each drug-food interaction is linked to a significance level code that indicates the interaction's level of risk. The drug-food interactions returned can be filtered to display only interactions of a specified significance level code.

• Most significant
  Documented (more clinical data may be needed): Action to reduce risk of adverse interaction usually required.
• More significant
  Documented (more clinical data may be needed): Assess risk to patient and take action as needed.
• Significant
  Documented (more clinical data may be needed): Conservative measures are recommended until more is known.