What is thrombocythemia?

Thrombocythemia is a disease in which your bone marrow makes too many platelets. Platelets are blood cell fragments that help with blood clotting. Having too many platelets makes it hard for your blood to clot normally. This can cause too much clotting or not enough clotting.

What causes thrombocythemia?

There may be no single cause for thrombocythemia. It is believed to be caused by defects in the bone marrow’s platelet-making cells.

What are the symptoms of thrombocythemia?

Symptoms of thrombocythemia include:

  • Blood clots in arteries and veins, most often in the hands, feet, and brain 

  • Bruising easily

  • Bleeding from the nose, gums, and GI (gastrointestinal) tract

  • Bloody stools

  • Bleeding after injury or surgery

  • Weakness

  • Headache and dizziness 

The symptoms of thrombocythemia may look like other blood disorders or health problems. Always see your healthcare provider for a diagnosis.

How is thrombocythemia diagnosed?

Your healthcare provider will take your health history and give you a physical exam. You may also have tests such as:

  • CBC (complete blood count). This test measures the amount of red blood cells, white blood cells, and platelets in your blood.

  • Blood smear. This test looks at the blood cells using a microscope.

  • Bone marrow aspiration or biopsy. This test may be done to see if your bone marrow is healthy. It involves taking a small sample of bone marrow fluid (aspiration) or solid bone marrow tissue (core biopsy). The sample is checked under a microscope.

How is thrombocythemia treated?

Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is.

Treatment generally is done to ease symptoms and reduce the risk of having blood clots. Treatment may include:

  • Low-dose aspirin. This treatment is for people who are at risk for clots.

  • Chemotherapy. This treatment often may be given as a pill or injected, or both. Oral chemotherapy medicine called hydroxyurea or anagrelide may be given with an injected medicine called interferon alpha. 

  • Plateletpheresis. This procedure removes platelets from your blood. It is rarely needed for this condition.

Living with thrombocythemia

Work with your healthcare provider to develop a treatment plan that meets your needs.

 It’s also important to:

  • Not smoke, which may increase the risk of blood clots

  • Control other health conditions such as high cholesterol, high blood pressure, and diabetes

  • Tell your healthcare provider if you notice bruising or other signs of bleeding

Key points about thrombocythemia

  • Thrombocythemia causes your body to make too many platelets in the bone marrow.

  • Too many platelets can cause blood clots or bleeding.

  • Symptoms include blood clots and signs of bleeding, such as bruises, bloody stools, and weakness.

  • There may be no single cause for the disease. It is believed to be caused by defects in the bone marrow’s platelet-making cells.

  • Treatment includes medicines to control the platelet count and, in rare cases, removing platelets from the blood.

Next steps

Tips to help you get the most from a visit to your healthcare provider:

  • Know the reason for your visit and what you want to happen.

  • Before your visit, write down questions you want answered.

  • Bring someone with you to help you ask questions and remember what your provider tells you.

  • At the visit, write down the name of a new diagnosis and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.

  • Know why a new medicine or treatment is prescribed and how it will help you. Also know what the side effects are.

  • Ask if your condition can be treated in other ways.

  • Know why a test or procedure is recommended and what the results could mean.

  • Know what to expect if you do not take the medicine or have the test or procedure.

  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.

  • Know how you can contact your provider if you have questions.

Online Medical Reviewer: L Renee Watson MSN RN
Online Medical Reviewer: Raymond Turley Jr PA-C
Online Medical Reviewer: Todd Gersten MD
Date Last Reviewed: 2/1/2021
© 2000-2023 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.