Other Name(s):

a-amino-b-[4-imidazole]-propionic acid


Histidine is 1 of the 9 essential amino acids people must get from food. It is in most protein-rich foods such as meat, fish, and eggs. It is also in soy, whole grains, beans, and nuts. It's used in growth, repair of damaged tissues, and making blood cells. It helps protect nerve cells. It's used by the body to make histamine. Histidine supplements may help treat eczema.

Recommended intake

Amino acids (AAs) are available as single AAs or in AA combinations. They also come as part of multivitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

By eating enough protein in your diet, you get all of the amino acids you need.

There are no conditions that increase how much histidine you need.

Side effects and toxicity

Using a single amino acid supplement may lead to negative nitrogen balance. This can lessen how well your metabolism works. It can make your kidneys work harder. In children, single amino acid supplements may cause growth problems.

Single amino acid supplements aren’t advised for people who eat an adequate amount of protein. You shouldn't take high doses of single amino acids for long periods of time.

Taking too much histidine may cause psychological issues. It may also lead to mood disorders.

People who are pregnant or breastfeeding shouldn’t use histidine supplements.

Online Medical Reviewer: Brittany Poulson MDA RDN CD CDE
Online Medical Reviewer: Heather M Trevino BSN RNC
Online Medical Reviewer: Rita Sather RN
Date Last Reviewed: 8/1/2023