Other name(s):

a-amino-b-hydroxy-propionic acid

General description

Serine is a nonessential amino acid. It occurs naturally in humans. Serine can be obtained from natural sources in the diet, such as meat, dairy, and wheat-based foods.

Unsubstantiated claims

Please note that this section reports on claims that have not yet been substantiated through studies.

Serine is a natural moisturizer. It’s included in many skin-care preparations.

Studies show that serine improves attention, arousal, verbal fluency, and memory in seniors with cognitive issues. The mechanism of action is unclear. More research is needed in this area.  

Recommended intake

Amino acids (AAs) are available as individual AAs or in AA combinations. They also come as part of multivitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

Note that by eating enough protein in your diet, you should get all the amino acids you need.

There are no conditions that increase how much serine you need.

Side effects, toxicity, and interactions

Using a single amino acid supplement may lead to negative nitrogen balance. This can decrease how efficient your metabolism is. It can also make your kidneys work harder. In children, taking single amino acid supplements may also cause growth problems.

You should not take high doses of individual amino acids for long periods of time.

People who are pregnant or breastfeeding shouldn’t use serine supplements.

Online Medical Reviewer: Brittany Poulson MDA RDN CD CDE
Online Medical Reviewer: Heather M Trevino BSN RNC
Online Medical Reviewer: Rita Sather RN
Date Last Reviewed: 8/1/2023